Multicolored redox active upconverter cerium oxide nanoparticle for bio-imaging and therapeutics.

نویسندگان

  • Suresh Babu
  • Jung-Hyun Cho
  • Janet M Dowding
  • Eric Heckert
  • Chris Komanski
  • Soumen Das
  • Jimmie Colon
  • Cheryl H Baker
  • Michael Bass
  • William T Self
  • Sudipta Seal
چکیده

Cytocompatible, co-doped cerium oxide nanoparticles exhibited strong upconversion properties that were found to kill lung cancer cells by inducing apoptosis thereby demonstrating the potential to be used as clinical contrast agents for imaging and as therapeutic agents for treatment of cancer.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine

The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic bi...

متن کامل

Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver

Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and ...

متن کامل

Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage

Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already ...

متن کامل

Extraordinarily high pseudocapacitance of metal organic framework derived nanostructured cerium oxide.

MOF derived CeO2 showed a pseudocapacitance of 1204 F g(-1) at 0.2 A g(-1), far exceeding its theoretical capacitance (560 F g(-1)). The present study demonstrates that combination of a two-way strategy, controlled nano-architecture and redox active electrolyte additive, could potentially alleviate both low energy density and capacitance fading issues plaguing the current metal oxide pseudocapa...

متن کامل

Toxicity of nano and bulk forms of cerium oxide in different cell lines

In recent years, nanotechnology has gained serious attention for diagnosis, prevention and treatment roles. In this study we synthesized nanoceria or CeO2NPs (cerium oxide nanoparticles) and compared toxicity of cerium oxide powder in nano and bulk forms in two cancerous and one normal cell lines. The cell lines were cultured in a standard humidified incubator, at 37 °C in a 5% CO2 atmosphere, ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 46 37  شماره 

صفحات  -

تاریخ انتشار 2010